Mass Effect: There will always be people telling you the fight is impossible. Fight anyway.
Assassin's Creed: Heroes can come from anywhere.
Fez: Sometimes solving a puzzle only takes looking at it from a different angle.
inFAMOUS: Give people second chances. They might surprise you.
Journey: The road may be long, but you don't have to walk it alone.
Civilization: Not all victories are the same.
Borderlands: Sometimes, you just need to laugh at yourself.
Minecraft: There is no limit to your imagination.
Skyrim: Practice makes perfect.
Pokemon: Friendship can overcome amazing odds.
Katamari Damacy: Even the smallest person can do something great.
Bioshock: Appearances can be deceiving. Even something that appears perfect can have deep flaws.
Dragon Age: Some things can't be changed. What matters is how you adapt to them.
Fallout: Even after the worst disasters, things can be rebuilt.
The Sims: No one man should have all that power.
The Last Of Us: Sometimes redemption comes from the most unexpected places.
Tetris: Do the best you can with what you have.
Portal: If you can't find a way, make your own.
flOw: Adaptation is the key to survival.
Professor Layton: Every puzzle has an answer and every problem has a solution.
Ace Attorney: Fight for what you know is right and bring the truth to light.
Shin Megami Tensei: You can pull through bad times, no matter how dark they may seem, and if your friends are assholes, get rid of them.
Drakengard 3: When suddenly a flower sprouts out of your eye, ask a Dragon to destroy it. NEVER TRY TO PULL IT OUT YOURSELF, BECAUSE YOU MIGHT END UP DESTROYING THE FUCKING WORLD.
Disgaea: Even the most vile person can change for the better if you show them kindness and love.